Regulatory Light Chain Mutants Linked to Heart Disease Modify the Cardiac Myosin Lever Arm
نویسندگان
چکیده
منابع مشابه
Congenital heart disease linked to maternal autoimmunity against cardiac myosin.
Structural congenital heart disease (CHD) has not previously been linked to autoimmunity. In our study, we developed an autoimmune model of structural CHD that resembles hypoplastic left heart syndrome (HLHS), a life-threatening CHD primarily affecting the left ventricle. Because cardiac myosin (CM) is a dominant autoantigen in autoimmune heart disease, we hypothesized that immunization with CM...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2013
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi301500d